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Article

Contribution of natural amino acid substitutions in SHV extended-spectrum beta-lactamases to resistance against various beta-lactams.

Antimicrobial agents and chemotherapy - 1 Oct 2000

Randegger C C, Keller A, Irla M, Wada A, Hächler H

Abstract excerpt

SHV extended-spectrum beta-lactamases (ESBLs) arise through single amino acid substitutions in the parental enzyme, SHV-1. In order to evaluate the effect of genetic dissimilarities around the structural gene on MICs, we had previously devised an isogenic system of strains. Here, we present an extended version of the system that now allows assessment of all major types of SHV beta-lactamases as well as of two...

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PMID: 10991857
DOI: 10.1128/AAC.44.10.2759-2763.2000
PMCID: PMC90148

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