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Article

Enzymatic analysis of the effect of naturally occurring Leu138Pro mutation identified in SHV β-lactamase on hydrolysis of penicillin and ampicillin.

BMC microbiology - 4 Feb 2011

Rayamajhi Nabin, Joo Jeong Chan, Cha Seung Bin, Pokherl Subarna, Shin Min Kyung, Yoo Young Je, Yoo Han Sang

Abstract excerpt

BACKGROUND: The aim of this study was to analyze the significance of leucine to proline substitution at position 138(Leu138Pro) on the hydrolysis of penicillin and ampicillin that we identified in the blaSHV gene of clinical Escherichia coli swine isolate. RESULTS: Kinetic analysis of the mutant proteins showed that K(m) value of the purified L138P mutant was comparatively higher than SHV-1, SHV-33 and...

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Identifiers

PMID: 21291571
DOI: 10.1186/1471-2180-11-29
PMCID: PMC3045869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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