Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping and characterizing a new DNA replication mutant in Saccharomyces cerevisiae.

Yeast (Chichester, England) - 1 Jan 2000

Eberly S L, Sakai A, Sugino A

Abstract excerpt

A detailed characterization of the mak1-3 mutation of Saccharomyces cerevisiae has been made possible by modifying its genetic background. The mak1-3 mutation, which confers temperature sensitivity for growth, was originally identified as one of four mak1 mutations (Wickner and Leibowitz, 1976). Mak1-1, 1-2 and 1-4 mutants are deficient in DNA topoisomerase I activity and thus have been renamed 'top1' (Thrash et...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to DNA, Fungal
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Mutation

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Temperature

Source

Identifiers

PMID: 2652918
DOI: 10.1002/yea.320050207

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Mapping and characterizing a new DNA replication mutant in Saccharomyces cerevisiae.PMID 2652918Read ↗

MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.Semantic proximity Read ↗

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.Semantic proximity Read ↗

A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).Semantic proximity Read ↗

Two mcm3 mutations affect different steps in the initiation of DNA replication.Semantic proximity Read ↗

Isolation, DNA sequence and regulation of a new cell division cycle gene from the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

A Saccharomyces cerevisiae mutant defective in the kinesin-like protein Kar3 is sensitive to NaCl-stress.Semantic proximity Read ↗

Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants.Semantic proximity Read ↗

MAK10, a glucose-repressible gene necessary for replication of a dsRNA virus of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs.Semantic proximity Read ↗

Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations.Semantic proximity Read ↗

Isolation and genetic characterisation of the Drosophila homologue of (SCE)REV3, encoding the catalytic subunit of DNA polymerase zeta.Semantic proximity Read ↗

Isolation of temperature-sensitive cell cycle mutants from mouse FM3A cells. Characterization of mutants with special reference to DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.