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Article

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.

Cell reports - 10 Nov 2015

Mou Zongyang, Hyde Thomas M, Lipska Barbara K, Martinowich Keri, Wei Peter, Ong Chiew-Jen, Hunter Lindsay A, Palaguachi Gladys I, Morgun Eva, Teng Rujia, Lai Chen, Condarco Tania A, Demidowich Andrew P, Krause Amanda J, Marshall Leslie J, Haack Karin, Voruganti V Saroja, Cole Shelley A, Butte Nancy F, Comuzzie Anthony G, Nalls Michael A, Zonderman Alan B, Singleton Andrew B, Evans Michele K, Martin Bronwen, Maudsley Stuart, Tsao Jack W, Kleinman Joel E, Yanovski Jack A, Han Joan C

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined human hypothalamic BDNF expression in association with 44 BDNF SNPs. We observed that the minor C allele of rs12291063 is associated with lower human ventromedial...

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Identifiers

PMID: 26526993
DOI: 10.1016/j.celrep.2015.09.065
PMCID: PMC4644471

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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