Article
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.
Diabetes - 1 Dec 2006
Gray Juliette, Yeo Giles S H, Cox James J, Morton Jenny, Adlam Anna-Lynne R, Keogh Julia M, Yanovski Jack A, El Gharbawy Areeg, Han Joan C, Tung Y C Loraine, Hodges John R, Raymond F Lucy, O'rahilly Stephen, Farooqi I Sadaf
Abstract excerpt
The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent models of BDNF disruption all exhibit increased food intake and obesity, as well as hyperactivity. We report an 8-year-old girl with hyperphagia and severe obesity, impaired cognitive function, and hyperact...
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