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Article

Human umbilical cord-derived mesenchymal stem cells elicit macrophages into an anti-inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats.

Stem cells (Dayton, Ohio) - 1 Mar 2016

Xie Zongyan, Hao Haojie, Tong Chuan, Cheng Yu, Liu Jiejie, Pang Yaping, Si Yiling, Guo Yulin, Zang Li, Mu Yiming, Han Weidong

Abstract excerpt

Insulin resistance, a major characteristic of type 2 diabetes (T2D), is closely associated with adipose tissue macrophages (ATMs) that induce chronic low-grade inflammation. Recently, mesenchymal stem cells (MSCs) have been identified in alleviation of insulin resistance. However, the underlying mechanism still remains elusive. Thus, we aimed to investigate whether the effect of MSCs on insulin resistance was...

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Identifiers

PMID: 26523620
DOI: 10.1002/stem.2238

Genes

MSC
STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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