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Article

Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands.

Experimental dermatology - 1 Mar 2016

Li Yong, Stoll Stefan W, Sekhon Sahil, Talsma Caroline, Camhi Maya I, Jones Jennifer L, Lambert Sylviane, Marley Hue, Rittié Laure, Grachtchouk Marina, Fritz Yi, Ward Nicole L, Elder James T

Abstract excerpt

To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5' and 3' untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG expression compared to an otherwise-identical construct containing only the coding region (AREG-CDR). AREG-UTR mice...

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Identifiers

PMID: 26519132
DOI: 10.1111/exd.12886
PMCID: PMC4789112

Genes

AREG
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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