Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.

1 Nov 1997

Abstract excerpt

Amphiregulin (AR) is a heparin-binding, heparin-inhibited member of the epidermal growth factor (EGF) family and an autocrine growth factor for human keratinocytes. Previous studies have shown that AR expression is increased in psoriatic epidermis. To test the hypothesis that aberrant AR expression is central to the development of psoriatic lesions, we constructed a transgene (K14-ARGE) encoding a human keratin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to HER2/EGFR in Cancer Research
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9410906
DOI: 10.1172/jci119766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.PMID 9410906Read ↗

Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands.Semantic proximity Read ↗

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.Semantic proximity Read ↗

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory ActivitySemantic proximity Read ↗

Metalloproteinase-Mediated, Context-Dependent Function of Amphiregulin and HB-EGF in Human Keratinocytes and SkinSemantic proximity Read ↗

Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration.Semantic proximity Read ↗

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasisSemantic proximity Read ↗

Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.Semantic proximity Read ↗

Transgenic mouse models support HCR as an effector gene in the PSORS1 locus.Semantic proximity Read ↗

Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.Semantic proximity Read ↗

From classical mouse models of psoriasis to a spontaneous xenograft model featuring use of AGR mice.Semantic proximity Read ↗

Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis.Semantic proximity Read ↗

AIRE Deficiency Leads to the Development of Alopecia Areata‒Like Lesions in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.