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Article

Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.

PLoS biology - 1 Aug 2007

Osborne Cameron S, Chakalova Lyubomira, Mitchell Jennifer A, Horton Alice, Wood Andrew L, Bolland Daniel J, Corcoran Anne E, Fraser Peter

Abstract excerpt

Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes migrate to preassembled transcription sites. We used fluorescent in situ hybridization to investigate the dynamics of gene association with transcription factories during immediate early (IE) gene...

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Share to B-Lymphocytes
Share to Genes, Immediate-Early

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Heavy Chains

Share to Proto-Oncogene Proteins c-myc

Share to RNA Polymerase II

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 17622196
DOI: 10.1371/journal.pbio.0050192
PMCID: PMC1945077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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