Article
Spatial allelic imbalance of BCL2 genes and chromosome 18 territories in nonneoplastic and neoplastic cervical squamous epithelium.
European biophysics journal : EBJ - 1 Jul 2009
Wiech Thorsten, Stein Stefan, Lachenmaier Victoria, Schmitt Eberhard, Schwarz-Finsterle Jutta, Wiech Elisabeth, Hildenbrand Georg, Werner Martin, Hausmann Michael
Abstract excerpt
Several studies suggest a correlation between genome architecture and gene function. To elucidate mechanisms of gene positioning during cell differentiation and malignant transformation we investigated the nuclear positions of the BCL2 alleles and chromosome 18 territories in different layers of nonneoplastic cervical squamous epithelium and cervical squamous carcinomas in relation to gene expression....
Topics
- Alleles
- Cell Differentiation
- Cell Nucleus
- Cervix Uteri
- Chromosomes, Human, Pair 18
- Epithelium
- Female
- Gene Expression
- Genes, bcl-2
- Humans
- Imaging, Three-Dimensional
- Immunohistochemistry
- In Situ Hybridization, Fluorescence