Article
Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2021
Yam Clinton, Yen Er-Yen, Chang Jeffrey T, Bassett Roland L, Alatrash Gheath, Garber Haven, Huo Lei, Yang Fei, Philips Anne V, Ding Qing-Qing, Lim Bora, Ueno Naoto T, Kannan Kasthuri, Sun Xiangjie, Sun Baohua, Parra Cuentas Edwin Roger, Symmans William Fraser, White Jason B, Ravenberg Elizabeth, Seth Sahil, Guerriero Jennifer L, Rauch Gaiane M, Damodaran Senthil, Litton Jennifer K, Wargo Jennifer A, Hortobagyi Gabriel N, Futreal Andrew, Wistuba Ignacio I, Sun Ryan, Moulder Stacy L, Mittendorf Elizabeth A
Abstract excerpt
PURPOSE: Increasing tumor-infiltrating lymphocytes (TIL) is associated with higher rates of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in patients with triple-negative breast cancer (TNBC). However, the presence of TILs does not consistently predict pCR, therefore, the current study was undertaken to more fully characterize the immune cell response and its association with pCR. EXPERIMENTAL...
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