Article
Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels.
The Journal of biological chemistry - 29 Jan 2016
Sihn Choong-Ryoul, Kim Hyo Jeong, Woltz Ryan L, Yarov-Yarovoy Vladimir, Yang Pei-Chi, Xu Jun, Clancy Colleen E, Zhang Xiao-Dong, Chiamvimonvat Nipavan, Yamoah Ebenezer N
Abstract excerpt
Calmodulin (CaM), a Ca(2+)-sensing protein, is constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate Ca(2+)-dependent reduction of Kv7 currents. However, the mechanism remains unclear. We report that CaM binds to two isoforms of the hKv7.4 channel in a Ca(2+)-independent manner but that only the long isoform (hKv7.4a) is regulated by Ca(2+)/CaM. Ca(2+)/CaM mediate...
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