Article

Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function

2023-01-29

Abstract excerpt

<h4>Rationale</h4> Missense variants in calmodulin (CaM) predispose patients to arrhythmias associated with high mortality rates. As CaM regulates several key cardiac ion channels, a mechanistic understanding of CaM variant-associated arrhythmias requires elucidating individual CaM variant effect on distinct channels. One key CaM regulatory target is the KCNQ1 (K V 7.1) voltage-gated potassium channel that under...

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Literature Corpus work: 307d160e-05cc-5c41-82aa-4dfa1ac8ca9d
DOI: 10.1101/2023.01.28.526031

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