Article
Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells.
Molecular oncology - 1 Feb 2016
Andriani Francesca, Bertolini Giulia, Facchinetti Federica, Baldoli Erika, Moro Massimo, Casalini Patrizia, Caserini Roberto, Milione Massimo, Leone Giorgia, Pelosi Giuseppe, Pastorino Ugo, Sozzi Gabriella, Roz Luca
Abstract excerpt
Cancer cells within a tumor are functionally heterogeneous and specific subpopulations, defined as cancer initiating cells (CICs), are endowed with higher tumor forming potential. The CIC state, however, is not hierarchically stable and conversion of non-CICs to CICs under microenvironment signals might represent a determinant of tumor aggressiveness. How plasticity is regulated at the cellular level is however...
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