Article
Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2012
Levine A Joan, Win Aung Ko, Buchanan Daniel D, Jenkins Mark A, Baron John A, Young Joanne P, Long Tiffany I, Weisenberger Daniel J, Laird Peter W, McCall Rebecca L, Duggan David J, Haile Robert W
Abstract excerpt
Methylation of the MLH1 gene promoter region is an underlying cause of colorectal cancer (CRC) with high microsatellite instability (MSI-H) diagnosed in persons without a germ line mutation in a mismatch repair (MMR) gene (non-Lynch Syndrome CRC). It is unclear whether relatives of CRC cases with MLH1 methylation have an increased risk of colorectal or other cancers. In this retrospective cohort study, we...
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