Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.

PloS one - 1 Jan 2015

Shigeyasu Kunitoshi, Nagasaka Takeshi, Mori Yoshiko, Yokomichi Naosuke, Kawai Takashi, Fuji Tomokazu, Kimura Keisuke, Umeda Yuzo, Kagawa Shunsuke, Goel Ajay, Fujiwara Toshiyoshi

Abstract excerpt

BACKGROUND: To improve the outcome of patients suffering from gastric cancer, a better understanding of underlying genetic and epigenetic events in this malignancy is required. Although CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) have been shown to play pivotal roles in gastric cancer pathogenesis, the clinical significance of these events on survival outcomes in patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Microsatellite Instability

Share to Multivariate Analysis

Share to MutL Protein Homolog 1

Share to Proportional Hazards Models

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26121593
DOI: 10.1371/journal.pone.0130409
PMCID: PMC4488282

Genes

MLH1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.PMID 26121593Read ↗

Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma.Semantic proximity Read ↗

Meta-analysis of the prognostic value of CpG island methylator phenotype in gastric cancer.Semantic proximity Read ↗

CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor PrognosisSemantic proximity Read ↗

Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.Semantic proximity Read ↗

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status.Semantic proximity Read ↗

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.Semantic proximity Read ↗

CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features.Semantic proximity Read ↗

The role of the CpG island methylator phenotype on survival outcome in colon cancer.Semantic proximity Read ↗

Molecular features and prognostic factors of locally advanced microsatellite instability-high gastric cancer.Semantic proximity Read ↗

Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation.Semantic proximity Read ↗

Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.Semantic proximity Read ↗

Biological significance of the CpG island methylator phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.