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Article

Lipid-Laden Multilocular Cells in the Aging Thymus Are Phenotypically Heterogeneous.

PloS one - 1 Jan 2015

Langhi Larissa G P, Andrade Leonardo R, Shimabukuro Marilia Kimie, van Ewijk Willem, Taub Dennis D, Borojevic Radovan, de Mello Coelho Valeria

Abstract excerpt

Intrathymic lipid-laden multilocular cells (LLMC) are known to express pro-inflammatory factors that might regulate functional activity of the thymus. However, the phenotype of age-associated intrathymic LLMC is still controversial. In this study, we evaluated LLMC density in the aging thymus and better characterized their distribution, ultrastructure and phenotype. Our results show an increased density of LLMC...

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Identifiers

PMID: 26509710
DOI: 10.1371/journal.pone.0141516
PMCID: PMC4624951

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UCP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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