Article
Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study.
Physiological genomics - 1 Jan 2016
Miller Virginia M, Jenkins Gregory D, Biernacka Joanna M, Heit John A, Huggins Gordon S, Hodis Howard N, Budoff Matthew J, Lobo Rogerio A, Taylor Hugh S, Manson JoAnn E, Black Dennis M, Naftolin Frederick, Harman S Mitchell, de Andrade Mariza
Abstract excerpt
Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid artery intima-medial thickness (CIMT) and coronary arterial calcification (CAC) in women (n = 606) enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Whether MHT might affect these associations is unknown. The association of treatment outcomes with...
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