Article
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
Journal of lipid research - 1 Mar 2010
Schoiswohl Gabriele, Schweiger Martina, Schreiber Renate, Gorkiewicz Gregor, Preiss-Landl Karina, Taschler Ulrike, Zierler Kathrin A, Radner Franz P W, Eichmann Thomas O, Kienesberger Petra C, Eder Sandra, Lass Achim, Haemmerle Guenter, Alsted Thomas J, Kiens Bente, Hoefler Gerald, Zechner Rudolf, Zimmermann Robert
Abstract excerpt
FAs are mobilized from triglyceride (TG) stores during exercise to supply the working muscle with energy. Mice deficient for adipose triglyceride lipase (ATGL-ko) exhibit defective lipolysis and accumulate TG in adipose tissue and muscle, suggesting that ATGL deficiency affects energy availability and substrate utilization in working muscle. In this study, we investigated the effect of moderate treadmill exercise...
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