Article
Raf: a strategic target for therapeutic development against cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2005
Beeram Muralidhar, Patnaik Amita, Rowinsky Eric K
Abstract excerpt
The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in transmitting proliferative signals generated by cell surface receptors and cytoplasmic signaling elements to the nucleus. Several important signaling elements of the MAPK pathway, particularly Ras and Raf, are...
Topics
- Animals
- Antineoplastic Agents
- Benzenesulfonates
- Down-Regulation
- Drug Delivery Systems
- Humans
- MAP Kinase Kinase 1
- MAP Kinase Signaling System
- Molecular Biology
- Mutation
- Neoplasms
- Niacinamide
- Phenylurea Compounds
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins A-raf
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-raf
- Pyridines