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Article

Raf: a strategic target for therapeutic development against cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2005

Beeram Muralidhar, Patnaik Amita, Rowinsky Eric K

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in transmitting proliferative signals generated by cell surface receptors and cytoplasmic signaling elements to the nucleus. Several important signaling elements of the MAPK pathway, particularly Ras and Raf, are encoded by oncogenes, and as such, their structures and functions can be modified, rendering them constitutively...

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Identifiers

PMID: 16170185
DOI: 10.1200/JCO.2005.08.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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