Article
Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Critical reviews in oncogenesis - 1 Jan 2012
Röring Michael, Brummer Tilman
Abstract excerpt
The Ras/Raf/MEK/ERK signaling pathway plays a key role in physiological processes and is often dysregulated in cancer as well as developmental disorders such as the neuro-cardio-facio-cutaneous syndromes. Raf proteins, and in particular B-Raf, represent an important regulatory node, which is refl...
Topics
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Drug Resistance, Neoplasm
- Humans
- Models, Biological
- Molecular Targeted Therapy
- Mutation
- Neoplasms
- Point-of-Care Systems
- Protein Kinase Inhibitors
- Proto-Oncogene Mas
- Proto-Oncogene Proteins B-raf
- Signal Transduction
- Time Factors
- Translational Research, Biomedical
- Validation Studies as Topic