Article
Recent advances in B-RAF inhibitors as anticancer agents.
Bioorganic chemistry - 1 Mar 2022
Khan Pathan Shahebaaz, Rajesh Patil, Rajendra Patil, Chaskar Manohar G, Rohidas Arote, Jaiprakash Sangshetti
Abstract excerpt
The significance of B-RAF in the promotion of cell proliferation and motility was explored by the researchers in the past. However, in 2002, several researchers found that mutation in B-RAF leads to cancer. Extensive research on B-RAF mutations suggested B-RAF V600E mutation as a critical predictive, prognostic and diagnostic biomarker in numerous cancers such as melanoma, thyroid, and colorectal cancers. Based...
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