Article

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling

2021-03-22

Abstract excerpt

Abstract: Oncogenic RAS mutations drive more than half of human cancers, and RAS inhibition is the holy grail of oncology. Thirty years of relentless efforts and harsh disappointments have taught us about the intricacies of oncogenic RAS signalling that allow us to now get a pharmacological grip on this elusive protein. The inhibition of effector pathways, such as the RAF-MEK-ERK pathway, has largely proven disapp...

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Literature Corpus work: f2633394-a57b-5a24-b0db-2b946cf74562
DOI: 10.20944/preprints202103.0510.v1

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