Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)

31 Jan 2019

Abstract excerpt

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, and despite optimized treatment options, median survival remains dismal. Contemporary evidence suggests disease recurrence results from expansion of a robustly radioresistant subset of GBM progenitor cells, termed GBM stem cells (GSCs). In this study, we utilized transmission electron microscopy to uncover ultrastructural effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30709011
DOI: 10.3390/cancers11020159

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)PMID 30709011Read ↗

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosisSemantic proximity Read ↗

Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?Semantic proximity Read ↗

Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) ConceptsSemantic proximity Read ↗

Glioblastoma and its treatment are associated with extensive accelerated brain agingSemantic proximity Read ↗

Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.Semantic proximity Read ↗

Redox-Regulated Pathways in Glioblastoma Stem-like Cells: Mechanistic Insights and Therapeutic ImplicationsSemantic proximity Read ↗

SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomesSemantic proximity Read ↗

Targeting Radiation-Induced Glioma-Initiating Cells in Patient-Derived GlioblastomaSemantic proximity Read ↗

Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastomaSemantic proximity Read ↗

Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathwaySemantic proximity Read ↗

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.Semantic proximity Read ↗

Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.