Article
Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma.
Cancer - 1 Feb 2016
Hakimi A Ari, Ostrovnaya Irina, Jacobsen Anders, Susztak Katalin, Coleman Jonathan A, Russo Paul, Winer Andrew G, Mano Roy, Sankin Alexander I, Motzer Robert J, Voss Martin H, Offit Kenneth, Purdue Mark, Pomerantz Mark, Freedman Matthew, Choueiri Toni K, Hsieh James J, Klein Robert J
Abstract excerpt
BACKGROUND: The exonic single-nucleotide variant rs11762213 located in the MET oncogene has recently been identified as a prognostic marker in clear cell renal cell carcinoma (ccRCC). This finding was validated with The Cancer Genome Atlas (TCGA) cohort, and the biologic implications were explored. METHODS: The genotype status for rs11762213 was available for 272 patients. Paired tumor-normal data, genomic data,...
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