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Article

MET expression and copy number status in clear-cell renal cell carcinoma: prognostic value and potential predictive marker.

Oncotarget - 3 Jan 2017

Macher-Goeppinger Stephan, Keith Martina, Endris Volker, Penzel Roland, Tagscherer Katrin E, Pahernik Sascha, Hohenfellner Markus, Gardner Humphrey, Grüllich Carsten, Schirmacher Peter, Roth Wilfried

Abstract excerpt

Multiple targeted therapy for advanced clear-cell renal cell carcinoma (RCC) has substantially improved patient outcome, but complete remission is uncommon and many tumors eventually develop resistance. Mechanistic, preclinical, and early clinical data highlight c-Met / hepatocyte growth factor receptor as a promising target for RCC therapeutic agents.We have examined MET expression, frequency of MET gene copy...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27894094
DOI: 10.18632/oncotarget.13540
PMCID: PMC5352033

Genes

MET

Provenance

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