Article
CA9 gene: single nucleotide polymorphism predicts metastatic renal cell carcinoma prognosis.
The Journal of urology - 1 Aug 2009
de Martino Michela, Klatte Tobias, Seligson David B, LaRochelle Jeffrey, Shuch Brian, Caliliw Randy, Li Zhenhua, Kabbinavar Fairooz F, Pantuck Allan J, Belldegrun Arie S
Abstract excerpt
PURPOSE: We assessed CA9 single nucleotide polymorphisms and mutations, and their association with CAIX protein expression, overall survival and response to interleukin-2 in white patients with metastatic clear cell renal cell carcinoma. MATERIALS METHODS: Genomic DNA was extracted from frozen tumor samples of 54 metastatic clear cell renal cell carcinomas. The CA9 gene exons and flanking regions were amplified...
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