Article
Impact of recurrent copy number alterations and cancer gene mutations on the predictive accuracy of prognostic models in clear cell renal cell carcinoma.
The Journal of urology - 1 Jul 2014
Hakimi A Ari, Mano Roy, Ciriello Giovanni, Gonen Mithat, Mikkilineni Nina, Sfakianos John P, Kim Philip H, Motzer Robert J, Russo Paul, Reuter Victor E, Hsieh James J, Ostrovnaya Irina
Abstract excerpt
PURPOSE: Several recently reported recurrent genomic alterations in clear cell renal cell carcinoma are linked to pathological and clinical outcomes. We determined whether any recurrent cancer gene mutations or copy number alterations identified in the TCGA (The Cancer Genome Atlas) clear cell renal cell carcinoma data set could add to the predictive accuracy of current prognostic models. MATERIALS AND METHODS:...
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