Article
Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.
American journal of respiratory and critical care medicine - 1 Mar 2015
Israel Elliot, Lasky-Su Jessica, Markezich Amy, Damask Amy, Szefler Stanley J, Schuemann Brooke, Klanderman Barbara, Sylvia Jody, Kazani Shamsah, Wu Rongling, Martinez Fernando, Boushey Homer A, Chinchilli Vernon M, Mauger Dave, Weiss Scott T, Tantisira Kelan G
Abstract excerpt
RATIONALE: β2-Agonists are the most common form of treatment of asthma, but there is significant variability in response to these medications. A significant proportion of this responsiveness may be heritable. OBJECTIVES: To investigate whether a genome-wide association study (GWAS) could identify novel pharmacogenetic loci in asthma. METHODS: We performed a GWAS of acute bronchodilator response (BDR) to inhaled...
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