Article
A genome-wide association study of bronchodilator response in asthmatics.
The pharmacogenomics journal - 1 Feb 2014
Duan Q L, Lasky-Su J, Himes B E, Qiu W, Litonjua A A, Damask A, Lazarus R, Klanderman B, Irvin C G, Peters S P, Hanrahan J P, Lima J J, Martinez F D, Mauger D, Chinchilli V M, Soto-Quiros M, Avila L, Celedón J C, Lange C, Weiss S T, Tantisira K G
Abstract excerpt
Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albuterol, 534 290 single-nucleotide polymorphisms (SNPs) were tested in 403 white trios from the Childhood Asthma Management Program using five statistical models to determine the...
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