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Article

Understanding c-MET signalling in squamous cell carcinoma of the head & neck

12 Jan 2017

Abstract excerpt

c-MET is a membrane spanning receptor tyrosine kinase for hepatocyte growth factor (HGF) also termed scatter factor. Transmitting signals from mesenchymal to epithelial cells, the HGF/c-MET axis mediates a range of biological processes that stimulate proliferation, motility, invasiveness, morphogenesis, apoptosis, and angiogenesis. Aberrant c-MET signal transduction favours tumorigenesis with the acquisition of...

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PMID: 28259294
DOI: 10.1016/j.critrevonc.2017.01.004

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