Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention.

doi:10.1002/jcb.240531007

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Article

Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention.

Journal of cellular biochemistry. Supplement - 1 Jan 1993

Boone C W, Kelloff G J

Abstract excerpt

Neoplasia is a progression of molecular, cellular, and tissue changes starting with a critical cell mutation and advancing by clonal evolution, involving further multiple mutations and expanding mutated clones. This process is characterized by five general stages: latency, focal growth of normal-...

Topics

Animals
Biomarkers, Tumor
Cell Division
Clone Cells
Diagnosis, Computer-Assisted
Epithelium
Flow Cytometry
Humans
Mutation
Neoplasm Staging
Neoplasms

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