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Article

Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention.

Journal of cellular biochemistry. Supplement - 1 Jan 1993

Boone C W, Kelloff G J

Abstract excerpt

Neoplasia is a progression of molecular, cellular, and tissue changes starting with a critical cell mutation and advancing by clonal evolution, involving further multiple mutations and expanding mutated clones. This process is characterized by five general stages: latency, focal growth of normal-appearing but disorganized cells, abnormal-appearing cells (dysplasia), microinvasion, and finally, metastasis. The two...

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Identifiers

PMID: 8412208
DOI: 10.1002/jcb.240531007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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