Article

Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice

2023-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Tenofovir (TFV) is a nucleotide reverse transcriptase inhibitor prescribed for the treatment and prevention of human immunodeficiency virus infection, and the treatment of chronic hepatitis B virus infection. Here, we demonstrate that creatine kinase brain-type (CKB) can form tenofovir-diphosphate (TFV-DP), the pharmacologically active metabolite, in vitro, and identify nine missense mutations (...

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Literature Corpus work: b8f5a1a5-8a41-5811-b6a9-f40748c22d4c
DOI: 10.1101/2023.09.25.559370

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