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Association of type 2 diabetes GWAS loci and the risk of Parkinson's and Alzheimer's diseases.

Parkinsonism & related disorders - 1 Dec 2015

Chung Sun Ju, Kim Mi-Jung, Kim Juyeon, Ryu Ho-Sung, Kim Young Jin, Kim Seong Yoon, Lee Jae-Hong

Abstract excerpt

BACKGROUND: Insulin and insulin-like growth factor contribute to normal brain function. Recent experimental and clinical studies showed that type 2 diabetes mellitus (T2DM) and Parkinson's disease (PD) or Alzheimer's disease (AD) share several dysregulated pathways. OBJECTIVE: We aimed to investigate whether genome-wide significant loci of T2DM are associated with the risk of PD and AD as well as the severity of...

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Source

Identifiers

PMID: 26499758
DOI: 10.1016/j.parkreldis.2015.10.010

Genes

KCNQ1
CDKAL1
FTO
GLIS3
HHEX
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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