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A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice

24 Oct 2015

Abstract excerpt

BACKGROUND: The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primitive endoderm lineage in the mammalian blastocyst. During gastrulation, GATA6 is expressed in early cardiac mesoderm and definitive endoderm progenitors, and is necessary for development of...

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PMID: 26498761
DOI: 10.1186/s12861-015-0086-5

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