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Article

Exome-Sequence Analyses of Four Multi-Incident Multiple Sclerosis Families.

Genes - 25 Aug 2020

Zrzavy Tobias, Leutmezer Fritz, Kristoferitsch Wolfgang, Kornek Barbara, Schneider Christine, Rommer Paulus, Berger Thomas, Zimprich Alexander

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the Central Nervous System (CNS). Currently, it is estimated that 30-40% of the phenotypic variability of MS can be explained by genetic factors. However, low susceptibility variants identified through Genome Wide Association Study (GWAS) were calculated to explain about 50% of the heritability. Whether familial high-risk variants also contribute...

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Identifiers

PMID: 32854198
DOI: 10.3390/genes11090988
PMCID: PMC7563748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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