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Article

Cofactor modification analysis: a computational framework to identify cofactor specificity engineering targets for strain improvement.

Journal of bioinformatics and computational biology - 1 Dec 2013

Lakshmanan Meiyappan, Chung Bevan Kai-Sheng, Liu Chengcheng, Kim Seon-Won, Lee Dong-Yup

Abstract excerpt

Cofactors, such as NAD(H) and NADP(H), play important roles in energy transfer within the cells by providing the necessary redox carriers for a myriad of metabolic reactions, both anabolic and catabolic. Thus, it is crucial to establish the overall cellular redox balance for achieving the desired cellular physiology. Of several methods to manipulate the intracellular cofactor regeneration rates, altering the...

Read the complete abstract on PubMed

Topics

Algorithms
Butanols
Butylene Glycols
Coenzymes
Computer Simulation
Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Engineering

Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)

Mathematical Computing

Mutation

Oxidation-Reduction

Propylene Glycols

Source

Identifiers

PMID: 24372035
DOI: 10.1142/S0219720013430063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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