Article
Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract.
Molecular medicine reports - 1 Dec 2015
Zhao Yunjing, Liu Xiaoliang, Sun Hongwei, Wang Yueping, Yang Wenzhu, Ma Hongwei
Abstract excerpt
The forkhead box protein P2 (FOXP2) gene encodes an important transcription factor that contains a polyglutamine (poly‑Q) tract and a forkhead DNA binding domain. It has been observed that FOXP2 is associated with speech sound disorder (SSD), and mutations that decrease the length of the poly‑Q tract were identified in the FOXP2 gene of SSD patients. However, the exact role of poly‑Q reduction is not well...
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