Article
Analysis of two language-related genes in autism: a case-control association study of FOXP2 and CNTNAP2.
Psychiatric genetics - 1 Apr 2013
Toma Claudio, Hervás Amaia, Torrico Bàrbara, Balmaña Noemí, Salgado Marta, Maristany Marta, Vilella Elisabet, Martínez-Leal Rafael, Planelles Ma Inmaculada, Cuscó Ivon, del Campo Miguel, Pérez-Jurado Luis A, Caballero-Andaluz Rafaela, de Diego-Otero Yolanda, Pérez-Costillas Lucía, Ramos-Quiroga Josep A, Ribasés Marta, Bayés Mònica, Cormand Bru
Abstract excerpt
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement of common variants of the Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription is regulated by the product of FOXP2, in several disorders characterized by...
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