Article
Impact of IL-8-251A/T gene polymorphism on severity of disease caused by enterovirus 71 infection.
Archives of virology - 1 Jan 2016
Xu Daoyan, Li Jian, Huang Xiangjuan, Lin Aiwei, Gai Zhongtao, Chen Zongbo
Abstract excerpt
The study was performed in EV71-infected patients, with 97 mild cases and 80 severe cases. IL-8251A/T genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism technique. Severe cases had a significantly higher frequency of the IL8-251 AT and TT genotypes than mild cases (52.5 % vs. 49.5 % and 42.5 % vs. 30.9 %, respectively; p = 0.024). The frequency of IL-8-251T alleles...
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