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Article

DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C-MET and HER3.

Journal of translational medicine - 24 Oct 2015

Yang Rachel L, Mick Rosemarie, Lee Kathreen, Graves Holly L, Nathanson Katherine L, Domchek Susan M, Kelz Rachel R, Zhang Paul J, Czerniecki Brian J

Abstract excerpt

BACKGROUND: Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in pure DCIS (pDCIS) and invasive breast cancer with concurrent DCIS (IBC + DCIS) in mutation carriers. METHODS: A cohort of BRCA1 and BRCA2 mutation carriers >18 years old who underwent surgery for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26496879
DOI: 10.1186/s12967-015-0698-3
PMCID: PMC4619378

Genes

BRCA1
BRCA2
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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