Molecular phenotypes of DCIS predict overall and invasive recurrence.

doi:10.1093/annonc/mdv062

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Article

Molecular phenotypes of DCIS predict overall and invasive recurrence.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2015

Williams K E, Barnes N L P, Cramer A, Johnson R, Cheema K, Morris J, Howe M, Bundred N J

Abstract excerpt

BACKGROUND: Molecular phenotypes of invasive breast cancer predict early recurrence. Ductal carcinoma in situ (DCIS) exhibits similar phenotypes, but their frequency and significance remain unclear. To determine whether DCIS molecular phenotypes predict recurrence, 314 women (median age 57.7 years) with primary DCIS who were screened or entered DCIS trials in a specialist breast unit from 1990 to 2010 were...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Chi-Square Distribution
Disease-Free Survival
England
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Kaplan-Meier Estimate

Ki-67 Antigen

Middle Aged

Molecular Diagnostic Techniques

Multivariate Analysis

Neoplasm Recurrence, Local

Source

Open in PubMed

Identifiers

PMID: 25678586
DOI: 10.1093/annonc/mdv062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25678586-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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