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Article

Age‐related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy

31 Oct 2013

Abstract excerpt

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by a progressive degeneration of the striatonigral, olivo-ponto-cerebellar, and autonomic systems. Glial cytoplasmic inclusions (GCIs) containing alpha-synuclein represent the hallmark of MSA and are recapitulated in mice expressing alpha-synuclein in oligodendrocytes. To assess if oligodendroglial expression of human wild-type...

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PMID: 24243499
DOI: 10.1002/syn.21719

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