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Article

A method to avoid errors associated with the analysis of hypermutated viral sequences by alignment-based methods.

Journal of biomedical informatics - 1 Dec 2015

Alinejad-Rokny Hamid, Ebrahimi Diako

Abstract excerpt

The human genome encodes for a family of editing enzymes known as APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like3). They induce context dependent G-to-A changes, referred to as "hypermutation", in the genome of viruses such as HIV, SIV, HBV and endogenous retroviruses. Hypermutation is characterized by aligning affected sequences to a reference sequence. We show that indels...

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Identifiers

PMID: 26494601
DOI: 10.1016/j.jbi.2015.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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