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Elucidation of the Gemcitabine Transporters of Escherichia coli K-12 and Gamma-Proteobacteria Linked to Gemcitabine-Related Chemoresistance

2024-06-05

Abstract excerpt

Gemcitabine (2',2'-difluoro-2'-deoxycytidine), a widely used anticancer drug, is considered as a gold standard in treating aggressive pancreatic cancers. Gamma-proteobacteria that colonize the pancreatic tumors contribute to chemoresistance against gemcitabine by metabolizing the drug to a less active, deaminated, form. The gemcitabine transporters of these bacteria are unknown to date. Furthermore,...

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Literature Corpus work
6bfdbcf5-6b38-5cbd-ac33-7b45625cb3f3
DOI
10.20944/preprints202406.0274.v1
Open publication

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Elucidation of the Gemcitabine Transporters of Escherichia coli K-12 and Gamma-Proteobacteria Linked to Gemcitabine-Related ChemoresistanceDOI 10.20944/preprints202406.0274.v1
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