Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Future prospects for mitosis-targeted antitumor therapies

12 Jun 2021

Abstract excerpt

Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts have been devoted to the development of new therapies that target proteins involved in cell cycle regulation and mitosis. Novel targeted antimitotic drugs include inhibitors of aurora kinase family, polo-like kinase 1, Mps1, Eg5, CENP-5 and the APC/cyclosome complex. While certain new inhibitors reached the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34129859
DOI: 10.1016/j.bcp.2021.114655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Future prospects for mitosis-targeted antitumor therapiesPMID 34129859Read ↗

Mitosis-targeted anti-cancer therapies: where they standSemantic proximity Read ↗

Targeting the Mitotic Catastrophe Signaling Pathway in CancerSemantic proximity Read ↗

Killing cells by targeting mitosis.Semantic proximity Read ↗

Cell Death Signaling and Anticancer TherapySemantic proximity Read ↗

Cell death pathologies: targeting death pathways and the immune system for cancer therapySemantic proximity Read ↗

Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis InductionSemantic proximity Read ↗

Mitotic Poisons in Research and MedicineSemantic proximity Read ↗

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule PoisonsSemantic proximity Read ↗

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumorsSemantic proximity Read ↗

Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?Semantic proximity Read ↗

A link between mitotic defects and mitotic catastrophe: detection and cell fateSemantic proximity Read ↗

Mechanisms of drug-induced mitotic catastrophe in cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.