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Mitotic Catastrophe in Malignant Epithelial Tumors: The Pathologist’s Viewpoint

7 Feb 2011

Abstract excerpt

Mitotic catastrophe is a common phenomenon occurring in tumor cells with impaired p53 function exposed to various cytotoxic and genotoxic agents. The defective p53 checkpoint causes improper segregation of chromosomes, resulting in aberrant mitosis, multiple micronuclei, multinucleate giant cells, and eventual necrosis-like death and centrosome aberration. Although various descriptions explaining mitotic...

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PMID: 21299346
DOI: 10.3109/01913123.2010.543753

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