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Article

Killing cells by targeting mitosis.

Cell death and differentiation - 1 Mar 2012

Manchado E, Guillamot M, Malumbres M

Abstract excerpt

Cell cycle deregulation is a common feature of human cancer. Tumor cells accumulate mutations that result in unscheduled proliferation, genomic instability and chromosomal instability. Several therapeutic strategies have been proposed for targeting the cell division cycle in cancer. Whereas inhibiting the initial phases of the cell cycle is likely to generate viable quiescent cells, targeting mitosis offers...

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Identifiers

PMID: 22223105
DOI: 10.1038/cdd.2011.197
PMCID: PMC3278741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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