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Mechanism of action of the multikinase inhibitor Foretinib.

Cell cycle (Georgetown, Tex.) - 1 Dec 2011

Dufies Maeva, Jacquel Arnaud, Robert Guillaume, Cluzeau Thomas, Puissant Alexandre, Fenouille Nina, Legros Laurence, Raynaud Sophie, Cassuto Jill-Patrice, Luciano Fréderic, Auberger Patrick

Abstract excerpt

Mitotic catastrophe (MC) is induced when stressed cells enter prematurely or inappropriately into mitosis and can be caused by ionizing radiation and anticancer drugs. Foretinib is a multikinase inhibitor whose mechanism of action is incompletely understood. We investigated here the effect of Foretinib on chronic myelogenous leukemia (CML) cell lines either sensitive (IM-S) or resistant (IM-R) to the tyrosine...

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Identifiers

PMID: 22101270
DOI: 10.4161/cc.10.23.18323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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