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Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?

19 Feb 2018

Abstract excerpt

Interfering with mitosis for cancer treatment is an old concept that has proven highly successful in the clinics. Microtubule poisons are used to treat patients with different types of blood or solid cancer since more than 20 years, but how these drugs achieve clinical response is still unclear. Arresting cells in mitosis can promote their demise, at least in a petri dish. Yet, at the molecular level, this type...

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PMID: 29459486
DOI: 10.15252/embr.201745440

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